Severe and Uncontrolled Asthma: Tailoring Therapies for Complex Patients (AAN)

Despite multiple FDA-approved biologics, uncertainty remains regarding biomarker interpretation, patient selection, comparative efficacy, and practical implementation. This activity addresses persistent gaps in clinicians’ ability to accurately identify severe and uncontrolled pediatric asthma, distinguish phenotypes and endotypes, and apply guideline-based strategies to tailor biologic therapy. This activity also reviews current GINA guidance, emerging pediatric trial data, and shared decision-making strategies to improve evidence-based treatment selection, reduce exacerbations, and optimize outcomes in children and adolescents with complex asthma.

This program is a collaboration between the American College of Allergy, Asthma & Immunology and the Allergy and Asthma Network (AAN).

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Session recorded on March 18, 2026
Speaker: Leonard Bacharier, MD, FACAAI

Price: FREE for members and non-members

Accreditation
The American College of Allergy, Asthma & Immunology (ACAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation
The American College of Allergy, Asthma & Immunology (ACAAI) designates this enduring material for a maximum of 1 AMA PRA Category 1 CreditTM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Target Audience

Primary Care Providers
Allied Health Professionals

Learning Objectives

Upon completion of this activity learners should be able to:

1.Define and differentiate severe and uncontrolled pediatric asthma using current GINA and ERS/ATS criteria and describe key asthma phenotypes and Type 2 inflammatory pathways.
2. Evaluate and interpret Type 2 biomarkers to guide selection of biologic therapies in children and adolescents with severe asthma.
3. Apply evidence from pediatric clinical trials to individualize biologic treatment decisions, incorporate shared decision-making, and assess therapeutic response to improve asthma outcomes.

Additional information
Disclosure: 

As required by the Accreditation Council for Continuing Medical Education (ACCME) and in accordance with the American College of Allergy, Asthma and Immunology (ACAAI) policy, all individuals in a position to control or influence the content of an activity must disclose all financial relationships with any ineligible company that have occurred within the past 24 months. 

Ineligible companies are those whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients. The ACCME does not consider providers of clinical service directly to patients to be Ineligible Companies. Examples of ineligible companies include: 
 
•    Advertising, marketing, or communication firms whose clients are ineligible companies
•    Bio-medical startups that have begun a governmental regulatory approval process
•    Compounding pharmacies that manufacture proprietary compounds
•    Device manufacturers or distributors
•    Diagnostic labs that sell proprietary products
•    Growers, distributors, manufacturers or sellers of medical foods and dietary supplements
•    Manufacturers of health-related wearable products
•    Pharmaceutical companies or distributors
•    Pharmacy benefit managers
•    Reagent manufacturers or sellers
  
The ACCME does not consider providers of clinical service directly to patients to be commercial interests. For more information, visit www.accme.org. All identified relevant relationships must be mitigated and the educational content thoroughly vetted for fair balance, scientific objectivity, and appropriateness of patient care recommendations. It is required that disclosure of or absence of relevant financial relationships be provided to the learners prior to the start of the activity.

Learners must also be informed when off-label, experimental/investigational uses of drugs or devices are discussed in an educational activity or included in related materials.

Disclosure in no way implies that the information presented is biased or of lesser quality. It is incumbent upon course participants to be aware of these factors in interpreting the program contents and evaluating recommendations. Moreover, expressed views do not necessarily reflect the opinions of the ACAAI. All identified relevant financial relationships with ineligible companies have been mitigated.

Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Attendance
Course opens: 
03/18/2026
Course expires: 
12/31/2027
Rating: 
0

All identified relevant financial relationships with ineligible companies have been mitigated.

Speaker:
Leonard Bacharier, MD, FACAAI
Advisor: Sanofi/Regeneron, AstraZeneca, Kinaset, Excellergy
Speaker: Sanofi/Regeneron
Research: Sanofi/Regeneron, AstraZeneca
Consultant: Sanofi/Regeneron, AstraZeneca

Moderator:
Tonya Nash, AAN Staff
No relevant financial relationships with ineligible companies to disclose

 

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Attendance
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