Basic mechanisms of itch and advances in clinical management
Annals of Allergy, Asthma & Immunology
February 2026 Volume 136, Issue 2, Pages 131-140 CME Review
Accreditation: The American College of Allergy, Asthma & Immunology (ACAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Designation: The American College of Allergy, Asthma & Immunology (ACAAI) designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Target Audience
Physicians involved in providing patient care in the field of allergy/asthma/immunology
Learning Objectives
At the conclusion of this activity, participants should be able to:
• Utilize the appropriate initial diagnostic approach for patients with generalized
pruritus without primary lesions.
• Employ the most effective systemic therapeutic options for rapidly controlling inflammatory
itch such as in atopic dermatitis or prurigo modularis.
• Select evidence-based first-line topical therapies for localized neuropathic itch presentations.
• Apply a structured diagnostic and therapeutic flowchart to distinguish between inflammatory,
neuropathic, systemic, and psychogenic causes of chronic pruritus.
Accreditation: The American College of Allergy, Asthma & Immunology (ACAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Designation: The American College of Allergy, Asthma & Immunology (ACAAI) designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Available Credit
- 1.00 AMA PRA Category 1 Credit™
- 1.00 Attendance

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